Former Farrer MP Sussan Ley has officially resigned from parliament and a byelection and voters will head to the polls to vote on her replacement.

An early announcement has come from Michelle Milthorpe who will stand as an Independent candidate at the Farrer by-election.

She said she'll be offering what she describes as “real representation, grounded in community and focused on outcomes”.

After coming within 0.19 per cent of turning Farrer into a marginal seat at the last election, and delivering significant swings across the electorate, including winning all booths in Albury and securing strong support with wins in Jindera, Corowa, Deniliquin and Leeton, Mrs Milthorpe said the message from voters is clear: "our region is ready for change".

“For too long, the people of Farrer have been left wanting,” Mrs Milthorpe said.

“Party politics too often gets in the way of practical outcomes.

"Our communities deserve a reliable and relatable representative; someone who listens, understands our regional context, and is prepared to do the work in Canberra to make policy better reflect life in rural and regional Australia.”

Mrs Milthorpe acknowledged the 24-year parliamentary career of Ms Ley, describing it as “a significant contribution to public life”.

"The ongoing instability and undermining of her leadership meant the Coalition sidelined regional communities as it focused on internal power struggles," she said.

“The Coalition has been consumed by its own internal contests at a time when people are crying out for leadership.

"Farrer's future cannot be an afterthought to party politics.”

Running as a community-backed Independent, Mrs Milthorpe said she is focused squarely on cost-of-living pressures, access to healthcare, aged care services, reliable telecommunications, water management, and sustainable environmental practices.

The byelection is expected to be at least a four-horse race with Liberal, National and One Nation parties likely to field a candidate.